ALL Drugs, Herbs, and Supplements for Anxiety / Depression

I compiled these lists because psychologists/psychiatrists rarely explain which medications are available and may even withhold information. These lists are non-exhaustive but contain most common substances. If any of these substances are legally available in your area, try them out one at a time until you find what substance and dosage works for your brain/body. 

These drugs are either officially indicated, OR off-label.

DO YOUR RESEARCH. Most doctors don't.

Also, see: Drugs/Psychedelics for Anxiety/Depression

Synthetic drugs for anxiety/depression

• Gabaergics
  Gabaergics are mainly used for anxiety or insomnia. Some can also give euphoric effects. As I understand it, GABAergics do not cause sexual dysfunction.
• Abecarnil 
• List of benzos on Wikipedia: https://en.wikipedia.org/wiki/Template:Benzodiazepines
• alprazolam
• Baclofen (indicated for muscle spasms, but Euphoria is listed as a common side-effect in the BNF 75, and it can also have anxiolytic effects.)
• Chlordiazepoxide
• Clobazam 
• clonazepam
• clorazepate
• diazepam
• Divaplon
• Eszopiclone (Lunesta)
• Fasiplon 
• gabapentin
• gabapentin enacarbil
• gabapentin prodrug
• Lorazepam
• midazolam
• mirogabalin
• Necopidem
• Nordazepam
• Nitrous Oxide
• (In behavioural tests of anxiety, a low dose of N2O is an effective anxiolytic, and this anti-anxiety effect is associated with enhanced activity of GABAa receptors, as it is partially reversed by benzodiazepine receptor antagonists. )
• oxazepam
• Pagoclone
• Panadiplon 
• Pazinaclone 
• phenibut
• piracetam
• pregabalin
• Saripidem
• Suproclone
• Suriclone (Suril)
• Taniplon 
• Tofisopam (does not have anticonvulsant, sedative, skeletal muscle relaxant, motor skill-impairing or amnestic properties.)
• Zaleplon
• ZK-93423
• Zolpidem
• Zopiclone
• Gabaergics (in development/research)
• CGS-20625 
• CGS-9896
• CL-218,872 
• DS-1  
• ELB-139 (LS-191,811)
• GBLD-345 
• L-838,417 
• Lorediplon 
• NS-2664 (LS-193,048) 
• NS-2710 (LS-193,970) 
• RWJ-51204 
• SB-205384 
• SL651498
• SX-3228
• TP-003 
• TP-13 
• TPA-023 (MK-0777)  
• Y-23684
• Stimulants
• methylphenidate
• dextroamphetamine
• Antihistamines
• Atarax (low risk of sexual side effects)
• Mirtazapine (also a Tetracyclic drug) (low risk of sexual side effects)

• Tricyclic Antidepressants
• Protriptyline
• Noxiptiline (brand names Agedal, Elronon, Nogedal)
• Nortriptyline 
• Amitriptyline
• Serotonin Agonists
• Buspirone (low risk of sexual side effects)
• Tetracyclic Antidepressants
• Trazodone
• SSRIs
• Citalopram
• Escitalopram
• Fluoxetine
• Fluvoxamine
• Fluvoxamine controlled release
• Paroxetine
• Sertraline
• Atypical antidepressants
• Tianeptine
• mianserin
• bupropion (low risk of sexual side effects)
• trazodone
• nefazodone
• opipramol
• agomelatine (low risk of sexual side effects)
• Serotonin Antagonists 
• pizotifen

• Serotonin Modulators
• Vilazodone (low risk of sexual side effects)
• Vortioxetine (low risk of sexual side effects)
• SNRIs
• Venlafaxine
• Desvenlafaxine
• Duloxetine
• (33.3% of duloxetine patients experienced sexual side effects compared to 43.6% of those receiving escitalopram and 25% of those receiving placebo).
• Opiates and Opioids
• Buprenorphine, sold under the brand name Subutex, among others
• MAOIs
• Nardil
• Parnate
• Selegiline (transdermal patch) (low risk of sexual side effects)
• Synthetic Cannabinoids
• Sativex
• Marinol
• Epidiolex

Antipsychotics

• Prochlorperazine (Efficacy established in patients with generalized anxiety disorder -- McEvoy GK, ed. Prochlorperazine. Bethesda, MD: American Society of Health-System Pharmacists; 2005:2342-3)

substituted benzamides

• Levosulpiride  (used for psychosis, schizophrenia, anxiety, dysthymia)

atypical antipsychotics  

• Sulpiride ( used in low dosage to treat anxiety and mild depression.)
• Amisulpride (schizophrenia,  dysthymia)

Others

• Ketamine (can be used for depression. It induces a trance-like state while providing pain relief, sedation, and memory loss.)
• Esketamine (In 2019, it was approved for the treatment of depression in adults in the United States. The cost of the nasal spray as of 2019 will be US$4,700 to $6,800 for the first month.)
• Dextromethorphan (most often used as a cough medicine but can give euphoric effects)

Unknown effect, might be of interest

• https://en.wikipedia.org/wiki/Substituted_piperazine
• Sultopride (trade names Barnetil, Barnotil, Topral) 
• T3 (Cytomel)
• T4 (Levoxyl), 
• DHEA to prop up adrenals
• Natural Dessicated Thyroid

Herbs and supplements for anxiety:

• 5HTP (griffonia simplicifolia)
• Cannabis (high-CBD edibles)
• CBD oil
• chamomile capsules
• GABA capsules (e.g NOW Foods GABA)
• glycine
• Holy basil extract
• hops capsules
• inositol
• Lavender capsules
• lion's mane mushroom
• Magnesium glycinate
• Magnesium oil + iodine = zen mode 
• Magnesium taurate
• Magnsieum citrate
• Lemonbalm/melissa capsules
• niacinamide
• Omega3
• ("Emmons recommends a dose of 2,000 to 4,000 mg or more when taken for mood problems")
• SAMe 200mg (S-Adenosyl-Methionine) 
• Suntheanine / L-Theanine
• taurine
• (take 600mg or more in a single serving)
• valerian extract capsules
• vitamin B6
• Vitamin D3 5000 IU
• (good for Seasonal Depression, adults should take 5,000 IU per day. )
• Vitamine C and E works against Oxidative stress

Probiotics for anxiety / depression:
When they give probiotics to mice suffering from autism symptoms, the autism symptoms either go completely away or are strongly ameliorated.

• Lactobacillus helveticus Rosell-52 ME

• Bifidobacterium longum Rosell-175 ME

•  Lactobacillus  acidophilus La14

• Lactobacillus  Rhamnosus R0011

• Lactobacillus helveticus R0052

•  Lactobacillus  casei Lc11

•   Lactobacillus  paracasei lpc37

•    Lactobacillus  plantarum lp115

•   Lactobacillus  salivarius ls33

•   Bifidobacterium  lactis BI04

•  Bifidobacterium  breve br03

•    Bifidobacterium  longum bb536

Misc info
Magnesium and vitamin K2 complement each other, as magnesium helps lower blood pressure, which is an important component of heart disease. So, all in all, anytime you're taking any of the following: magnesium, calcium, vitamin D3, or vitamin K2, you need to take all the others into consideration as well, since these all work synergistically with one another.
Magnesium is required for the biological activation of Vitamin D.
Calcium and magnesium are necessary for muscle function and nervous system health. If you don't have enough, you can have problems with clenching, tension, and other muscle problems.

• "by using vitamin B3 or niacin or niacinamide, which has effect upon gaba receptors but, after ive started especially With magnesium, manganese and lithium, ive needed much less diazepam when i first use it"

• Kent Holtorf MD says on twitter: "T3 is the best anti-depressant".

Please inform me if you know about a substance not present in the blog post above.

Drugs/Psychedelics for Anxiety/Depression

Psilocybin & Magic Mushrooms
Writing in the Journal of Psychopharmacology, the Johns Hopkins researchers note that most of the 36 volunteer subjects given psilocybin, under controlled conditions in a Hopkins study published in 2006, continued to say 14 months later that the experience increased their sense of well-being or life satisfaction.
"Most of the volunteers looked back on their experience up to 14 months later and rated it as the most, or one of the five most, personally meaningful and spiritually significant of their lives," says lead investigator Roland Griffiths, Ph.D., a professor in the Johns Hopkins departments of Psychiatry and Behavioral Sciences and Neuroscience.
Griffiths also notes that, "while some of our subjects reported strong fear or anxiety for a portion of their day-long psilocybin sessions, none reported any lingering harmful effects, and we didn't observe any clinical evidence of harm."


<Johns Hopkins Medical Institutions. "Spiritual Effects Of Hallucinogens Persist, Researchers Report." ScienceDaily 2 July 2008. 16 December 2010. http://www.sciencedaily.com­/releases/2008/07/080701083522.htm>

Psilocybin, aka magic mushrooms, actually calms, rather than stimulates, certain brain functions. Psychedelics, and psilocybin in particular, might actually be eliminating what could be called the extra "noise" in the brain. 


LSD-assisted Psychotherapy
Swiss psychiatrist Peter Gasser and his colleagues conducted the double-blind, placebo-controlled study, sponsored by the non-profit Multidisciplinary Association for Psychedelic Studies (MAPS). They tracked 12 people who were near the end of life as they attended LSD-assisted psychotherapy sessions. In his report, Gasser concluded that the study subjects’ anxiety "went down and stayed down."


MDMA 
The drug MDMA (aka ecstasy, or Molly) promotes release of the "love" hormone oxytocin, which could help treat severe anxieties like PTSD, and social anxiety resulting from autism.

Ayahuasca
The results of the first North American observational study on the safety and long-term effectiveness of ayawaska treatment for addiction and dependence were published in June 2013 in the journal Current Drug Abuse Reviews. All of the participants in the study reported positive and lasting changes, and the study found statistically significant improvements “for scales assessing hopefulness, empowerment, mindfulness, and quality of life meaning and outlook subscales. 

Cannabis
Cannabis strains high in CBD are well suited for reducing anxiety. If you have access to legal medicinal cannabis you have to try it, you have nothing to lose.

Anti-Septics are bad

Dr. Ruebush deplores the current fetish for the hundreds of antibacterial products that convey a false sense of security and may actually foster the development of antibiotic-resistant, disease-causing bacteria. Plain soap and water are all that are needed to become clean, she noted.

“I certainly recommend washing your hands after using the bathroom, before eating, after changing a diaper, before and after handling food,” and whenever they’re visibly soiled, she wrote. When no running water is available and cleaning hands is essential, she suggests an alcohol-based hand sanitizer.

Dr. Weinstock goes even further. “Children should be allowed to go barefoot in the dirt, play in the dirt, and not have to wash their hands when they come in to eat,” he said. He and Dr. Elliott pointed out that children who grow up on farms and are frequently exposed to worms and other organisms from farm animals are much less likely to develop allergies and autoimmune diseases. Also helpful, he said, is to “let kids have two dogs and a cat,” which will expose them to intestinal worms that can promote a healthy immune system.
("Babies Know: A Little Dirt Is Good for You" -- Jane E. Brody, NY Times <http://www.nytimes.com/2009/01/27/health/27brod.html?em>. 26 January 2009)

Philosophical, inspirational, mind-expanding movies

non-exhaustive list

1. Waking Life

Alternative Cancer Treatment

Western Medicine should not be disregarded, for science has given us extraordinary tools of healing. However, in need of medical treatment, why constrict your choices to just western medical science? Seek outside the comfort zone of the medical establishment and you might perchance upon something that works for you. Life, uh, finds a way.

The condition of the organism receiving treatment with either method also plays a big role. Do they have access to clean food? Pure water? Do they believe and feel they can overcome their disease? These are all important factors with any treatment. Even the bedside manners of the doctor affects the patient's recovery and treatment success rate. Positive thinking is also key.

Non-exhaustive list of alternative cancer treatment follows below. It is recommended to thoroughly research each item by yourself and evaluate the claims at your own discretion.

GARLIC
http://www.cancer.gov/cancertopics/factsheet/prevention/garlic-and-cancer-prevention

PH BALANCE
- Learn to maintain your PH and you can prevent and reverse disease such as cancer. A PH between 7.2 and 7.4 is optimal for best health.
- Dr. Robert J. Gillies and his colleagues have already demonstrated the effectiveness of baking soda in alkalinizing the area around tumors in mice. The same researchers found that bicarbonate increases tumor pH and also inhibits spontaneous metastases in mice with breast cancer. [3]
- Lemon is also used to help balance Ph. They are taken together as it is believed that lemon is one of the safest ways to introduce high alkaline substances into the system. These methods of treatment are able to approach carcinogenic cells and destroy them without destroying healthy cells. This is another key factor as chemotherapy destroys all cells which includes the healthy ones.


CANNABIS
Seems extremely divisive unless i'm completely dumb
https://www.startpage.com/do/dsearch?query=cannabis+cures+cancer&cat=web&pl=opensearch&language=english

CANCER IS A FUNGUS?
- Simoncini has a book: “Cancer Is A Fungus”. He claims all tumors are nothing more than colonies of Candida fungus which are highly “acid”. Baking Soda is one of the most alkaline substances known that destroys tumors (Candida fungus) in less than six days and they don’t return.

TURMERIC

BITTER MELON
Bitter melon juice diluted to just 5% in water showed remarkable potency in severely damaging all four pancreatic cancer cell lines researchers tested. The bitter melon reduced the viability of two cancer cell lines by 90%, while it knocked off the other two lines by a staggering 98%. And it did so after just 72 hours of treatment!

APRICOT KERNELS
Apricot kernels are, like most nuts and seeds, very nutritious. Among the nutrients they contain is one called amygdalin, which is also known as vitamin B17. This attacks cancer cells, and thus can help prevent cancer from breaking out in our bodies.


GRAPE SEEDS
A study published in the journal Carcinogenesis shows that grape seed extract (GSE) kills squamous cell carcinoma cells, while leaving healthy cells unharmed.

Shiitake mushrooms
Shiitake contain lentinan which not only strengthens the immune system, but, according to the American Cancer Society, is believed to slow tumor growth. The fungus, native to Asia, is also a good source of iron and antioxidants, which help reduce the damage from free radicals.

Reishi
has shown to contribute to the healing of tumors, while lowering blood sugar and cholesterol levels.

Lactarius salmonicolor
Commonly known as “Turkey Tail”, the mushroom has traditionally been used in Asian herbal remedies. According to the American Cancer Society, two extracts from the mushroom—polysaccharide K (PSK) and polysaccharide-peptide (PSP)—are under evaluation for cancer treatments.

Milk Thistle
An herb that is often processed into capsule form, milk thistle is thought to help delay the growth of cancerous tumors, thanks to its richness in the antioxidant silymarin, according to National Cancer Institute.

Anti-CD47 cancer therapy clinical trials
http://stemcell.stanford.edu/CD47/


POLIO kills cancer?
injecting polio into a tumor may kill the tumor

HIV/AIDS kills cancer?
injecting a modified HIV/AIDS virus may kill lymphoma and leukemia

Alan Watts on Anxiety (audio)

​These chapters from "Out of your mind" audio lecture series ​by Alan Watts touch on anxiety and social anxiety:

1-07 An Independent System
2-02 Being Aware Of Awareness
2-03 Captivated By The Drama
2-04 The Game Of Hide And Seek
2-06 How Do We Define Ourselves
3-03 A Spontaneous Life
3-04 Seeing Beyond Our Separateness
4-06 What Game Would You Like To Play
5-07 Of Pain And Suffering
5-08 Must Life Go On And On
5-09 A Natural Satori
6-04 The Illusion Of The Ego
6-05 The Meaningless Life
7-05 The Origins Of Zen
10-05 The Limits Of Self-Awareness
11-04 The Cause Of Suffering
12-08 Consider Death Now