These drugs are either officially indicated, OR off-label.
DO YOUR RESEARCH. Most doctors don't.
Also, see: Drugs/Psychedelics for Anxiety/Depression
Synthetic drugs for anxiety/depression
- Gabaergics
Gabaergics are mainly used for anxiety or insomnia. Some can also give euphoric effects. As I understand it, GABAergics do not cause sexual dysfunction. - Abecarnil
- List of benzos on Wikipedia: https://en.wikipedia.org/wiki/Template:Benzodiazepines
- alprazolam
- Baclofen (indicated for muscle spasms, but Euphoria is listed as a common side-effect in the BNF 75, and it can also have anxiolytic effects.)
- Chlordiazepoxide
- Clobazam
- clonazepam
- clorazepate
- diazepam
- Divaplon
- Eszopiclone (Lunesta)
- Fasiplon
- gabapentin
- gabapentin enacarbil
- gabapentin prodrug
- Lorazepam
- midazolam
- mirogabalin
- Necopidem
- Nordazepam
- Nitrous Oxide
- (In behavioural tests of anxiety, a low dose of N2O is an effective anxiolytic, and this anti-anxiety effect is associated with enhanced activity of GABAa receptors, as it is partially reversed by benzodiazepine receptor antagonists. )
- oxazepam
- Pagoclone
- Panadiplon
- Pazinaclone
- phenibut
- piracetam
- pregabalin
- Saripidem
- Suproclone
- Suriclone (Suril)
- Taniplon
- Tofisopam (does not have anticonvulsant, sedative, skeletal muscle relaxant, motor skill-impairing or amnestic properties.)
- Zaleplon
- ZK-93423
- Zolpidem
- Zopiclone
- Gabaergics (in development/research)
- CGS-20625
- CGS-9896
- CL-218,872
- DS-1
- ELB-139 (LS-191,811)
- GBLD-345
- L-838,417
- Lorediplon
- NS-2664 (LS-193,048)
- NS-2710 (LS-193,970)
- RWJ-51204
- SB-205384
- SL651498
- SX-3228
- TP-003
- TP-13
- TPA-023 (MK-0777)
- Y-23684
- Stimulants
- methylphenidate
- dextroamphetamine
- Antihistamines
- Atarax (low risk of sexual side effects)
- Mirtazapine (also a Tetracyclic drug) (low risk of sexual side effects)
- Tricyclic Antidepressants
- Protriptyline
- Noxiptiline (brand names Agedal, Elronon, Nogedal)
- Nortriptyline
- Amitriptyline
- Serotonin Agonists
- Buspirone (low risk of sexual side effects)
- Tetracyclic Antidepressants
- Trazodone
- SSRIs
- Citalopram
- Escitalopram
- Fluoxetine
- Fluvoxamine
- Fluvoxamine controlled release
- Paroxetine
- Sertraline
- Atypical antidepressants
- Tianeptine
- mianserin
- bupropion (low risk of sexual side effects)
- trazodone
- nefazodone
- opipramol
- agomelatine (low risk of sexual side effects)
- Serotonin Antagonists
- pizotifen
- Serotonin Modulators
- Vilazodone (low risk of sexual side effects)
- Vortioxetine (low risk of sexual side effects)
- SNRIs
- Venlafaxine
- Desvenlafaxine
- Duloxetine
- (33.3% of duloxetine patients experienced sexual side effects compared to 43.6% of those receiving escitalopram and 25% of those receiving placebo).
- Opiates and Opioids
- Buprenorphine, sold under the brand name Subutex, among others
- MAOIs
- Nardil
- Parnate
- Selegiline (transdermal patch) (low risk of sexual side effects)
- Synthetic Cannabinoids
- Sativex
- Marinol
- Epidiolex
Antipsychotics
- Prochlorperazine (Efficacy established in patients with generalized anxiety disorder -- McEvoy GK, ed. Prochlorperazine. Bethesda, MD: American Society of Health-System Pharmacists; 2005:2342-3)
substituted benzamides
- Levosulpiride (used for psychosis, schizophrenia, anxiety, dysthymia)
atypical antipsychotics
- Sulpiride ( used in low dosage to treat anxiety and mild depression.)
- Amisulpride (schizophrenia, dysthymia)
Others
- Ketamine (can be used for depression. It induces a trance-like state while providing pain relief, sedation, and memory loss.)
- Esketamine (In 2019, it was approved for the treatment of depression in adults in the United States. The cost of the nasal spray as of 2019 will be US$4,700 to $6,800 for the first month.)
- Dextromethorphan (most often used as a cough medicine but can give euphoric effects)
Unknown effect, might be of interest
- https://en.wikipedia.org/wiki/Substituted_piperazine
- Sultopride (trade names Barnetil, Barnotil, Topral)
- T3 (Cytomel)
- T4 (Levoxyl),
- DHEA to prop up adrenals
- Natural Dessicated Thyroid
Herbs and supplements for anxiety:
- 5HTP (griffonia simplicifolia)
- Cannabis (high-CBD edibles)
- CBD oil
- chamomile capsules
- GABA capsules (e.g NOW Foods GABA)
- glycine
- Holy basil extract
- hops capsules
- inositol
- Lavender capsules
- lion's mane mushroom
- Magnesium glycinate
- Magnesium oil + iodine = zen mode
- Magnesium taurate
- Magnsieum citrate
- Lemonbalm/melissa capsules
- niacinamide
- Omega3
- ("Emmons recommends a dose of 2,000 to 4,000 mg or more when taken for mood problems")
- SAMe 200mg (S-Adenosyl-Methionine)
- Suntheanine / L-Theanine
- taurine
- (take 600mg or more in a single serving)
- valerian extract capsules
- vitamin B6
- Vitamin D3 5000 IU
- (good for Seasonal Depression, adults should take 5,000 IU per day. )
- Vitamine C and E works against Oxidative stress
Probiotics for anxiety / depression:
When they give probiotics to mice suffering from autism symptoms, the autism symptoms either go completely away or are strongly ameliorated.
- Lactobacillus helveticus Rosell-52 ME
- Bifidobacterium longum Rosell-175 ME
- Lactobacillus acidophilus La14
- Lactobacillus Rhamnosus R0011
- Lactobacillus helveticus R0052
- Lactobacillus casei Lc11
- Lactobacillus paracasei lpc37
- Lactobacillus plantarum lp115
- Lactobacillus salivarius ls33
- Bifidobacterium lactis BI04
- Bifidobacterium breve br03
- Bifidobacterium longum bb536
Misc info
Magnesium and vitamin K2 complement each other, as magnesium helps lower blood pressure, which is an important component of heart disease. So, all in all, anytime you're taking any of the following: magnesium, calcium, vitamin D3, or vitamin K2, you need to take all the others into consideration as well, since these all work synergistically with one another.
Magnesium is required for the biological activation of Vitamin D.
Calcium and magnesium are necessary for muscle function and nervous system health. If you don't have enough, you can have problems with clenching, tension, and other muscle problems.
- "by using vitamin B3 or niacin or niacinamide, which has effect upon gaba receptors but, after ive started especially With magnesium, manganese and lithium, ive needed much less diazepam when i first use it"
- Kent Holtorf MD says on twitter: "T3 is the best anti-depressant".
Please inform me if you know about a substance not present in the blog post above.
